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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

17,21 Significant reductions in BP as a consequence of weight loss also allow health care providers to manage hypertension more effectively, potentially decreasing the need for multiple antihypertensive medications

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It does not appear to have toxic effects on the major organs, and it does not affect the endocrine (hormonal) system significantly

For example, it may take two to four weeks for sleep quality to improve and several months until skin improvements become noticeable
