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2.2 Entry of ascorbate into brain cells Once in the CSF, ascorbate appears to enter the brain interstitium by diffusion, since interstitial brain ascorbate concentrations of 200-400 M are similar to or only slightly higher than those in the CSF [53,54]
Indeed some reports suggest that the GSTM1 genetic polymorphism may affect AFB 1 detoxification in human liver
doi: 10.1016/j.biopha.2022.114048 155 WangLLiuJMaDZhiXLiLLiSet al
Beyond direct antioxidant activity, glutathione plays a central role in phase II liver detoxification the conjugation reactions that convert fat-soluble toxins, heavy metal compounds, and drug metabolites into water-soluble forms for excretion
[DOI] [PMC free article] [PubMed] [Google Scholar] 181.Khalid M., Petroianu G., Adem A
it is also required for optimal pyruvate dehydrogenase complex activation (41)
