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Activated glial cells further release pro-inflammatory mediators and impair neuronal glucose metabolism, which may directly regulate the central fatigue circuits in the insular cortex and prefrontal cortexkey brain regions mediating the perception of fatigue and cognitive function

Using a multi-omics analysis and genetic manipulations, another study identified early 2 factor transcription factor 4 (E2F4), transcriptional enhanced associate domain transcription factor 1 (TEAD1) and activating protein-1 (AP-1) to be key factors regulating the RS transcriptome and epigenome

Thus, it seems clear that the new drug targets discovery based on biogerontology represents an incredible opportunity for industries in healthcare and pharmacy

doi: 10.1007/s11547-017-0846-3

Melatonin in ventricular and subarachnoid cerebrospinal fluid: its function in the neural glymphatic network and biological significance for neurocognitive health