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It should also be noted that there is evidence suggesting that the intake of high doses of folic acid, and the resulting increase in the levels of unmetabolized folic acid, may have potential adverse effects on normal folic acid metabolism and immune function

Mild symptoms may improve with conservative care, especially if constipation or straining is the main trigger

Grasp these comparisons helps researchers select the most appropriate tools for their specific research questions

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doi:10.1016/j.stress.2024.100630

10.1167/iovs.63.4.27 69 WangL.ZhangL.NiuY.SitiaR.WangC