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MGF (Mechano Growth Factor) is a splice variant of the IGF-1 gene expressed in mechanically stressed muscle tissue

These insights are reflected in recent TME physiologic MRI studies showing that approximately two-thirds of vital GBM tumor tissue is dominated by aerobic glycolysis, with a glycolysis-to-OxPhos ratio of 38% to 19%, while a significant 24% of the tumor also displays hypoxia (53)

[25] Metabolic effects [edit] As a major growth factor, IGF1 is responsible for stimulating growth of all cell types, and causing significant metabolic effects