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Exposure to CSE perturbed the formation of tight junctions, leading to an increase in cell volume, a decrease in transepithelial electrical resistance (TER) in the human corneal epithelial cell-transformed (HCE-T) cell line

Kusumi, M., Nakashima, K., Harada, H., Nakayama, H
Cold Spring Harb Protoc
However, the gastrointestinal side effects (vomiting, diarrhea) can cause dehydration that worsens kidney function

In the elderly, hypothyroidism is associated with accelerated cognitive decline and an increased risk of Alzheimer's disease, raising the possibility that impaired thyroid signaling may act as a modifiable risk factor for dementia (83)
a similar effect was also observed with OGDH glutathionylation [10]
