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The G subunits are involved in the opening of G protein-coupled inward rectifying potassium channels (GIRKs) and the inhibition of voltage-gated calcium channels (VGCCs), resulting in hyperpolarization of the plasmatic membrane, a further decrease in neurotransmitter release, and a potentiation of the analgesic effect [39]

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The tissue distribution of the mrna of ghrelin and subtypes of its receptor, ghs-r, in humans