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[PubMed] [Google Scholar] 88.Konstantinopoulos PA, Kominea A, Vandoros G, Sykiotis GP, Andricopoulos P, Varakis I, Sotiropoulou-Bonikou G, Papavassiliou AG

Over time the therapeutic window for controlling the symptoms of Parkinson disease narrows, resulting in increased episodes of dyskinesias when dopamine levels rise too high, and reemergence of rigidity (akinesia) when synaptic levels of dopamine fall too low