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In the previous study, we also reported that plasma level of TNF-peaked at 6 h in both group and gradually decreased later than 12 h (Obayashi et al
The receptors for the natriuretic factors are integral plasm membrane proteins, whose intracellular domains possess intrinsic guanylate cyclase activity that catalyzes the formation of cGMP from GTP following natriuretic factor-binding

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Abbreviations: LINEs, long interspersed nuclear elements
