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Immune cells, especially macrophages, upregulate ENaC and have ENaC-mediated sodium influx as a requirement for NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome activation, and eventually, secretion of IL-1, which can lead to or worsen renal inflammation [50]

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low-dose NAMPT inhibition with FK866 can alleviate age-related cognitive impairment by enhancing autophagy and reducing neuroinflammation 219