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Inflammatory regulation effect of NAC on COVID-19 treatment (INFECT-19)

Animals and Description of Groups Institute of Cancer Research (ICR) mice (6 weeks, male) were purchased from Orient Bio (Seongnam, Korea) and bred at the Korea University Central Laboratory Animal Center (temperature: 2026 C, humidity: 4060%, illumination: 200300 lux)

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N 5 -Methyltetrahydrofolate Synthesis The conversion of 5,10-methylene-THF to 5-methyl-THF is catalyzed by methylene THF reductase (encoded by the MTHFR gene)

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49,62,63,64,65 In the Wnt/PCP pathway, the activation of small G proteins Rho or Rac1 triggers the activation of c-Jun N-terminal kinase (JNK), which in turn plays a critical role in the rearrangement of the actin cytoskeleton and regulating cell polarity and promoting migration