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The activated ZBP1 can interact with the RIP homotypic interaction motif (RHIM) domain of both RIPK1 and RIPK3 to mediate the NF-B activation and necroptotic cell death [100, 102, 104]

Indeed, in a current paper, we present that healthy aged rats develop reduced fever, furthermore its pattern is different from that in young rats

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Granadillo VA, Tahn JE, Salgado O et al (1995) The influence of the blood levels of lead, aluminum and vanadium upon the arterial hypertension

Thanks to these, it was possible to infer the effect of single mutations, allowing researchers to advance in the understanding of the biological bases underpinning this complex syndrome