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In summary, tubulin binders are the most widely used payloads among ADCs, being selected for 8 out of 15 marketed ADCs (53.3%) and 11 out of 24 ADCs in phase III clinical trials (45.8%)

Santomasso BD, Nastoupil LJ, Adkins S, Lacchetti C, Schneider BJ, Anadkat M, et al

That distinction is the most important mechanistic lesson of the entire program

In vitro studies are conducted outside a living organism, usually done in a made-up and controlled environment like a test tube or a petri dish

Harvey AE, Lashinger LM, Hursting SD (2011) The growing challenge of obesity and cancer: an inflammatory issue