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doi: 10.1186/1475-2891-13-20 111 Wachtel-GalorS.BenzieI

FIGURE 3 7.1 Flavonoids: multitarget antioxidants and metabolic regulators Flavonoids exert hepatoprotective effects through synergistic mechanisms that include direct ROS scavenging, activation of antioxidant pathways, and metabolic regulation

A 2000 study involving obese Zucker rats concluded that Fragment 176-191 did not negatively impact insulin sensitivity [11], while a 2001 study involving obese mice found that insulin secretion was unaffected [12]

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[28] Metal ion binding [edit] Beyond the iron-sulfur proteins, many other metal cofactors in enzymes are bound to the thiolate substituent of cysteinyl residues