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Similarly, in PD, -syn aggregates localize to mitochondria, impair mitochondrial dynamics, and increase oxidative stress, which together trigger BAX/BAK-mediated MOMP [81]

Convergence has been reported at the levels of STAT5 and SOCS3 (61) as well as on the major insulin signaling pathway: insulin receptor substrates (IRS) 1 and 2, PI 3-kinase, Akt, and extracellular regulated kinases (ERK) 1 and 2 (62,63)

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