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Furthermore, the same test subjects failed to respond when MSG was given with food. A systematic review of over 60 studies that purported to examine the effects of MSG ingestion on asthma failed to demonstrate a link, however only two studies met the reviewers rigorous inclusion criteria. A recent placebo-controlled study of individuals who self-reported an irregular heartbeat, atrial fibrillation (AF), in association with MSG consumption, demonstrated no association between AF and doses of 3 g of MSG. Bottom line: There is no reproducible scientific evidence that the general population or even self-identified MSG-sensitive individuals, are adversely affected by ingestion of MSG with food or on an empty stomach

Funding This project was financially supported by the National Natural Science Foundation (No.82174429, 82274573), Traditional Chinese Medicine Treatment of Advantageous Diseases (Clinical Evidence-Based Capacity Improvement) Project(No.2022-QNQSDEP-03)

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Malondialdehyde (MDA) is a byproduct of lipid peroxidation and serves as an important marker for oxidative stress in cells and tissues ( Figure 3A )