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Lactate shuttling links histone Kla, particularly H4K12la, to neural stem cells (NSCs) proliferation through murine double minute 2 (MDM2)-p53 signaling pathway and eventually regulates cell cycle and endows NSCs neurogenic potential in the adult hippocampus

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This translational benefit is particularly relevant for the long-term management of patients with mitochondrial dysfunction, who are predisposed to systemic metabolic decline (65)

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Applications in the a.m

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savoir, la carnitine alimentaire a un taux dabsorption plus grand que la carnitine prise en complment

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Nevertheless, therapeutic hypothermia is only partially effective (5760), and many infants with HIE remain at substantial risk of death or severe long-term neurodevelopmental impairments (55)

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29 MullerM

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