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Animal data is interesting

Triple-Hormone-Receptor Agonist Retatrutide for Obesity, Phase 2 trial

This may explain why various human protocols using different doses all report positive outcomes

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An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size

The bioavailability differs, the dosing schedule changes from weekly to daily, and the evidence base is less robust