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p63 is a member of the tumor suppressor family which includes p53 and p73 and while it was discovered much later than the others, p63 appears to be the original member of this family from which p53 and p73 evolved [14-17]

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Altogether these data suggest that gut microbiota is crucial in preserving the integrity of the IEB, thus preventing the systemic spreading of potentially harmful antigens

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This combination has not been formally studied in clinical trials, but the biological rationale is sound based on what we know about both modalities