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At that point, the question shifts from: What can suppress this pain? to What does this pain require in order to resolve? That shift marks the beginning of durable recovery

Author reply to Correspondence

doi: 10.1074/jbc.M112.341982

The generation of oxygen radicals is normally mitigated by the presence of adequate endogenous antioxidant defenses [37]

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MTHFR, or the methylenetetrahydrofolate reductase is the key regulatory enzyme in folate and homocysteine metabolism