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8,11 The protein adducts formed, specifically those of mitochondrial protein adducts, lead to oxidative injury and hepatocellular necrosis
Aerobic organisms generate ROS as products or by-products of mitochondrial respiration, xanthine oxidase, NADPH oxidase, and other metabolic processes and enzymes (911)
For K562 cells, UK-5099 treatment was sufficient to bring down the cellular level of GSH

Furthermore, it has been found that S-adenosyl-l-methionine (SAM) can provide a methyl group for the conjugation reaction

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