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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

Improved Tolerance: IV Iron formulations bypass gastrointestinal irritation associated with oral iron

Particle size-dependent and surface charge-dependent biodistribution of gold nanoparticles after intravenous administration

However, their modest efficacy in slowing GA lesion growth without demonstrating clear functional benefit, the burden of monthly or bi-monthly intravitreal injections, and potential safety concerns, including an increased risk of conversion to neovascular AMD, have limited their clinical use and precluded regulatory approval in Europe

K.ChenevertT.et al (2003)