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This knowledge coupled with the demonstration that some members of the 6-AH family bound with high affinity to the hinge region of HGF led to the expectation that other active AngIV analogs, like 6-AH family members, could be expected to inhibit HGF dimerization and that the ability of an individual analog to bind HGF and inhibit HGF-dependent processes should be reflected in its capacity to attenuate dimerization

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In other words, by maintaining the supply of available actin monomers, TB-500 provides a fast reaction for cell movement in the direction of the signal to migrate

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Prolonged vomiting or diarrhoea can lead to dehydration and, in some cases, acute kidney injury (AKI)
[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Jimenez A.G
