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( Anaesthesia, 2021 ) report that the epidemiology of local anesthetic systemic toxicity (LAST) is shifting, with delayed onset increasingly common, a growing proportion of cases arising from fascial plane and field blocks, and more events occurring outside the operating room and involving non-anesthesiologists

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Marchetti P, Castedo M, Susin SA, Zamzami N, Hirsch T, Macho A, Haeffner A, Hirsch F, Geuskens M, Kroemer G (1996) Mitochondrial permeability transition is a central coordinating event of apoptosis

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