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Setting: The treatment must be done in a proper hospital or clinic setting under the supervision of a healthcare professional

Although studies show that the mutations in those genes modulate the risk to develop neuropathy following vincristine to some degree, additional sufficiently powered studies may be required to validate the association between these genetic polymorphisms and pediatric peripheral neuropathy

Patients reported a lack of energy to perform their daily work and fatigue during rest [29]

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There are other studies indicating that SOCS1 and SOCS6 proteins inhibited the signaling of InsR [41], whereas SOCS2 and SOCS3 proteins suppressed that of IGF-1R [42, 43] (Figs

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