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The first injection on the new compound may produce mild differences in side effect profile because of vehicle differences between manufacturers, but these typically settle within 1 to 2 weeks

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5-amino-1MQ showed concentration-dependent inhibition of NNMT in fully differentiated adipocytes that could be fit to a 3-parameter sigmoidal dose-response curve with a calculated EC50=2.3+/1.1 M (permeable NNMT inhibitorFIGS

Collectively, these results provide a novel foundation for future investigations

Design, synthesis, ADME characterization and antileishmanial evaluation of novel substituted quinoline analogs

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