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Togashi Y, Shitara K, Nishikawa H

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Imran M, Ghorat F, Ul-Haq I, Ur-Rehman H, Aslam F, Heydari M, et al

CFTR participates in spermatogenesis, and evidence suggests its involvement in seminiferous intratubular fluid control, maintenance of the bloodtestis barrier, and improvement in follicle-stimulating hormone signalling, among other functions

Serotonin synthesis was increased

So it easy to be absorbed by skin through cell membrane and directly acting on skin