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A20 is a regulator of necroptosis

Adenosine triphosphate (ATP) is the principal source of this energy, the majority of which comes from the anaerobic metabolism of glucose

their deposition causes deleterious effects on neurodegenerative diseases, diabetes, arthritis, and cell damage through involving the NF-B, MAPKs, and Keap1-Nrf2-ARE etc

Here, we demonstrated that long-term oscillating glucose challenge in vivo resulted in desensitization of insulin secretion due to -cell mass exhaustion, which was caused by -cell dedifferentiation

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Woutersen RA, Appelman LM, Feron VJ, & der Heijden CA (1984) Inhalation toxicity of acetaldehyde in rats