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Species-specific factors profoundly influence both efficacy and safety profiles
Adams HP Jr, Bendixen BH, Kappelle LJ, et al
In these cases, glutathione (GSH) levels are well below the normal concentration and therefore feedback inhibition of GCL is absent

doi: 10.1086/313757 350 SahuS

Synthetic lethality and metabolic targeting Synthetic lethality, a genetic interaction in which simultaneous perturbation of two genes or pathways causes cell death while perturbation of either alone is tolerated, represents a powerful therapeutic strategy in cancer

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