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We extracted the following methodological features of each article: the mean age of participants, the percentage of male participants, the diagnostic system used to make diagnoses, the method of diagnosis (structured interview vs

Interleukin-8 (IL-8), a potent proinflammatory cytokine released in response to injury, has a key role in the recruitment and activation of neutrophils during inflammation [54, 55]

This timing may help maintain consistency and reduce the risk of missing a dose