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Reportedly, serum and urine levels of citrulline, ornithine, threonine, and methionine were found decrease substantially following both single (10 mg/kg, i.p.) and escalating (10, 12.5, 15, 20, and 30 mg/kg, i.p.) administration of MA, returning to baseline levels after a 2-day withdrawal period in Sprague Dawley rats 49

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51 Drug-interactions In animal models, ALC appears to play a role in the modulation of neurotransmitters and may lead to an increase in serotonin levels in the cerebral cortex

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Oxidative stress can change neuronal pathways and cause addictive behaviour