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Mice and diets All animal care and use procedures were approved by the Institutional Animal Care and Use Committee of Capital Medical University and were conducted in a specific-pathogen-free facility at Anzhen Hospital, Capital Medical University, Beijing, China

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Progranulin protects against renal ischemia/reperfusion injury in mice

For intracellular staining, cells were fixed with IC fixation buffer (Fisher Scientific), permeabilized and incubated in the dark with a fluorochrome-labelled antibody cocktail in 1 permeabilization buffer (Fisher Scientific) for 30 min at room temperature

A skin biopsy was performed (Figure 2), which confirmed the diagnosis of losartan-induced DRESS syndrome