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Additionally, busulfan can decrease Bcl-2 gene expression (as an antiapoptotic gene) and increase Bax gene expression (as a proapoptotic gene) in epididymal sperm of busulfan treated mice, which are related to increased oxidative stress as a result of decreased enzymatic antioxidants of GPx and SOD and increased level of lipid peroxidation in sperm cell (50)
(PubMed) Xu Y, Jiang W, Chen G, et al
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Less severe SLC22A5 mutations can cause skeletal muscle problems or cardiomyopathy
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