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Rosenfeld SV, Togo EF, Mikheev VS, Popovich IG, Khavinson VKh, Anisimov VN

Conclusions and perspective Almost 90 years after its initial discovery, NAD + is emerging as a central metabolite in the ageing field, and NAD + level decline is becoming an established feature of several age-associated diseases

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In vitro treatment of CD38-overexpressing CHO cells (CHO-mCD38) with Ab68, but not Ab69, significantly increased both cellular NAD + levels and Sirt1 and Sirt3 deacetylase activity (Fig

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