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Beyond mitochondria, several intracellular enzymes contribute to the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS): NADPH oxidases, xanthine oxidoreductase, certain peroxisomal oxidases, cytochrome P450 enzymes, cyclooxygenases, and lipoxygenases

Apparently trauma also can be a trigger

Efficacy of prolonged release melatonin in insomnia patients aged 5580 years: quality of sleep and next-day alertness outcomes

Gastroenterology 160:24962508 Firat O, Makay O, Yeniay L, Gokce G, Yenisey C, Coker A (2017) Omega-3 fatty acids inhibit oxidative stress in a rat model of liver regeneration

Zinc sulphate delays anagen-related eumelanin production, induces hair hypopigmentation in mice, and accelerates wound healing