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[DOI] [PMC free article] [PubMed] [Google Scholar] 160.Cooney R.V., Dai Q., Gao Y.-T., Chow W.-H., Franke A.A., Shu X.-O., Li H., Ji B., Cai Q., Chai W., et al

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Even though the exact causes of fibromyalgia are not fully understood, novel studies suggest that the disease results from altered sensory processing combined with several factors (e.g., genetics and environment) [17,18]

Additionally, berberine exhibits anti-inflammatory effects by inhibiting microglial activation, reducing TNF-, IL-1, and IL-6 levels, and attenuating the NF-B pathway in the injured brain (Li et al., 2023a)

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