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Notably, normal rats exhibited a superior sagittal sinus pressure in a range from 24 to 27 mmHg, and a portal pressure of 35 mmHg similar to that of the inferior vena cava, though with at least 1 mmHg higher values in the portal vein

10.1124/jpet.102.045559 [DOI] [PubMed] [Google Scholar] Li J., Li J.-G., Chen C., Zhang F., Liu-Chen L.-Y

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This often leads to weight gain or makes it harder to lose weight, even with diet and exercise