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In contrast, when PKM2 exists in its monomeric or dimeric form, it can enter the nucleus and function as a coactivator for several transcription factors (such as HIF-1, -catenin/c-Myc, NF-B, and STAT3), regulating metabolic reprogramming and gene expression to meet various physiological demands [49]

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Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease

10.1007/s00018-011-0689-3 Cell Mol

These investigations are conducted strictly within controlled laboratory environments to support structured analysis of peptide-driven signaling activity, receptor interaction dynamics, and downstream pathway modulation under defined experimental conditions

Peptide quantities were unit normalized and hierarchically clustered using the Pearson correlation in Cluster 3.0 (Eisen et al , 1998)