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In mouse models, boosting NAD+ has been shown to reverse DNA damage, reduce mutation load, and extend lifespan in progeroid models of aging

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doi: 10.3390/molecules26040916 [DOI] [PMC free article] [PubMed] [Google Scholar] 82.Costa C, Cunha S, Moreira J, et al

Decreased energy charge is sensed in cells via AMPK that is a master regulator of cellular energy homeostasis [77]

Thiol donors and analogues (GSH and mucolytic medications, such as N-acetyl-L-cysteine, nacystelyn, erdosteine, and carbocysteine lysine salt), dietary polyphenols, and flavonoids (curcumin, resveratrol, green tea-catechins, quercetin) have all been shown to scavenge and detoxify free radicals and oxidants, raise intracellular thiol levels, regulate NF-\( \kappa \) activation, and ultimately suppress the expression of inflammatory genes [102] (Table 3)

Thus, studying the expression of resistance genes can elucidate the molecular mechanisms that underlay cancer resistance, including their functional roles in cancer cells and normal cells and the conditions under which they are expressed