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2a) while no effect was observed in RAMP1/3 KO mice

In summary, we introduce a programmed targeting nanosystem based on a sequentially responsive liposome to dual rectify the abnormal energy and stromal microenvironments via coordinated regulation of GLUT1 and NF-B signal in PDAC cells and PSC, thus improving the anti-cancer efficacy of PDAC

In phase I, enzymes such as cytochrome P450 monooxygenase (P450s) and carboxylesterase act directly on the toxin molecule, catalyzing the oxidation, reduction, and chemical cleavage of toxins, thereby increasing the reactivity and hydrophilicity of the toxin 11,12

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