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Similar to NFU1 patients, the OXPHOS profile in cultured skin fibroblasts and skeletal muscle displayed a decreased activity of complexes I and II

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Even with a single point mutation, correcting enzyme dysfunction is inherently challenging

Edetate Calcium Disodium (usp) 124
It is primarily the stromal cells that produce extracellular matrix and form fibrotic scar tissue

A standalone B-complex tablet wont reliably correct or prevent the deficiency the protocol is designed to head off
