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The positive correlation between IGF-1 expression and cancer has been widely reviewed with one study that included 18 years of follow-up reporting a 1.82-fold risk of cancer mortality among men who had a baseline IGF-1 level above 100 ng/mL compared with men with lower levels, a risk that was increased to 2.61 for men who had a baseline IGF-1 level over 200 ng/mL [51]

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We therefore propose that tissue-associated oxidative stress may promote conversion of circulating TTR into dsNNTTR locally within the interstitial compartment, rather than exclusively during intracellular synthesis or processing

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