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Nrf1 is required for basal expression of GS in the mouse (Kwong et al., 1999) and Nrf1 and Nrf2 overexpression induced the human GS promoter activity (Lee et al., 2005)

& Wang, Q

The fibrous bands that were dissolved with QWO were shown to not grow back after 18 months and currently there is no expectation that they would, making the improvement in cellulite after treatment with QWO to be long term
Despite these promising outcomes, the study is limited by the lack of mechanistic insights, detailed optimization, and comprehensive toxicity evaluation, which are essential for practical implementation
