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In addition, the combination of HTX derivatives, such as HTX-ac and HBET, inhibited the heat stress-activated mitochondrial apoptosis pathway by regulating the expression of Bcl-2 family proteins and cytochrome c release, probably through modulation of the PKA-CREB-BDNF pathway [118,119]

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Active breakouts with pus or nodules: When inflammation is more intense, acne can progress into pustules or deeper nodules