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NAM increases SIRT1 activity via NNMT and 1-MNA (4)

As noted by Kraus et al., Nature Medicine and Ng et al., Journal of Endocrinology , targeting both systemic metabolism and localized fat cell activity may enhance fat-loss outcomes beyond either approach alone

This makes it easier to maintain lean mass while cutting and helps combat metabolic syndrome

Scientific References Kraus D, Yang Q, Kong D, et al

The association between nicotinamide N-methyltransferase gene polymorphisms and primary hypertension in Chinese Han Population