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Irinotecan disrupts tight junction proteins within the gut: implications for chemotherapy-induced gut toxicity

Additionally, in the DHE staining results, we observed that FOXO4-DRI treatment effectively reduced the ROS levels in the aorta of aged mice (Figure 2F)

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Assassi et al., CTGF , HGF , MMP12, which encode known regulators of fibrotic responses, and in IRAK1 and NLRP1 , which encode proteins involved innate immune responses (Fonseca et al., 2007