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An area of particular interest is the coagulation machinery

10.1101/pdb.prot070029 112 WuG

Thats because it doesnt act on the androgen receptor or interfere with the hypothalamic-pituitary-gonadal (HPG) axis

Figure 1 How Neuropeptides and the Prefrontal Cortex Power Executive Focus and Cognitive Longevity The executive brain runs on chemical signals

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Even though there are no formal (full) charges, this uneven pull creates a partial negative charge on one atom and partial positive on the other (as the electron density is unevenly distributed)
