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Liver damage begins within 24 h of a large overdose, producing right upper quadrant pain and tenderness

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During metabolism, redox cycling of PQ generates reactive oxygen species and initiates lipid peroxidation (Figure 4

Unresponsive vessels were excluded

BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation

When the gut lining is inflamed and permeable, neurotransmitter production is disrupted, inflammatory cytokines cross into systemic circulation and reach the brain, and the vagus nerve the primary communication cable between gut and brain transmits distress signals that manifest as anxiety, brain fog, and fatigue