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This discrepancy may arise in part because the majority of B12 in serum is bound to the transport protein haptocorrin which is not physiologically active and thus unavailable for B12-dependent enzymatic reactions in cells (Green et al., 2017)

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10.3389/fphar.2020.01171 7 BuzkovaJ.NikkanenJ.AholaS.HakonenA

In rare cases, some people may have an allergic reaction