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Pinch firmly enough to create a distinct fold but not so hard that it hurts

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OPTOVITE (injectable B12) package insert The administration of folic acid to patients with cobalamin deficiency induces hematological improvement but worsens the neurological picture. Source: de Paz R, Hernndez-Navarro F

The practice is very popular in Asia where IV drips are offered in beauty salons, often by unlicensed and unqualified practitioners

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+ The needle used is short and fine, and most patients describe the sensation as a quick pinch or a sharp pressure that lasts about a second